Theodor Herman Meynert (1833-1892)
The idea of an emergent property of the mind from whole brain (cortical) activity is already described by Meynert in his 1884 textbook Psychiatrie. Klinik der Erkrankungen des Vorderhirns, there he mentions “. . If we look upon the cortex as an organ functioning as a whole then the information that it subserves the processes of the mind is all that can be said . . . to think further about the cortex is impossible and unnecessary . .”
Meynert was one of the first clinicians to relate mental functions directly to neuronal network activity. He coined the term “Ego” as a function of a neuronal network of associations in which consciousness (experiences and associations) are embedded in connectivity organization of the brain “…. The main function of the central organ is to transmit the fact of existence to an ego gradually shaping itself in the stream of the brain…… ”
He related thoughts and experiences to associations among neuronal network activations, and was probably first to describe psychosis as weakening of connections among these network activations (later known as disconnection syndrome). As such he was the forefather of computational psychiatry by connecting a functional neuronal network model to clinical phenomology in psychiatry. In this he laid the first insights to the idea of Brain Profiler which is destined to fully develop and validate neuronal network disturbances as the causes of mental disorders.